Department of Chemical Engineering
1280 Main Street West, Hamilton
Ontario, Canada L8S 4L7
voice: (905) 525-9140 ext.26333
B.A.Sc. Chemical Engineering, Waterloo (1995), M.Sc.
Biology, Guelph (1998), Ph.D.Chemical Engineering,
From biomedical devices to drug delivery to regenerative medicine (tissue
engineering), biomaterials are serving increasingly complex roles. Beyond
merely providing structure, biomaterials are now integrated as scaffolds
or particles that deliver biologically active agents (cells, drugs or
antigens) in “combination products”. Thus, the body’s
response to the biomaterial will govern the effectiveness of these next
generation applications. I am interested in exploring the causes and effects
of the host response to biomaterials in order to guide future design using
biology as a framework.
1. Causes of biomaterial-induced inflammation
On a molecular level, what causes inflammation after biomaterial implantation?
We have been dissecting the contributions of adsorbed proteins, particle
size and patterns associated with the biomaterial itself. We hypothesize
that some biomaterials are recognised as pathogen associated molecular
patters through receptors of innate immunity. In order to create biologically-relevant
design criteria, we must identify the initiators of inflammation.
2. Effects of biomaterial-induced inflammation – adaptive
Activation of innate immunity by biomaterials will alter adaptive immune
responses to accompanying antigens or immune-mismatched cells. In tissue
engineering, the biomaterial scaffold will influence the rejection response
to an allogeneic functional cellular component. We are exploring how and
why different biomaterials alter cellular rejection. Ultimately, by engineering
biomaterials and cells, we aim to generate tissue-engineered constructs
that resist rejection.
Given that most biomaterials activate innate-type responses that are
known to guide adaptive immunity, we have also been investigating natural
and synthetic polymers as vaccine adjuvants to deliver antigens. By controlling
the innate activation and targeting delivery, we aim to rationally design
adjuvants that tune immune responses, facilitating vaccination against
diseases such as AIDS, malaria and cancer.
3. Effects of biomaterial-induced inflammation – fibrosis
A serious clinical problem after biomaterial implantation is scarring
or fibrosis. It can interfere with device function and is likely to retard
regeneration in tissue engineering applications. We are curious as to
the links between biomaterial-induced inflammation and fibrosis. We have
been using tools developed to investigate chronic fibrotic diseases to
explore this mechanism.
Regenerative Medicine Today
Recently submitted papers
Dong, Y and Jones, KS. Effect of serum and structure on macrophages response
to alginate. Submitted to Journal of Biomedical Materials Research: Part
Farooqui, N, Davies L and Jones KS. The in vitro effects of biomaterials
on lymphocyte responses to an allogeneic challenge. Submitted to Tissue
McLean, D.,Jones KS, Hoare T, and Pelton R. Amphoteric Microgels as Adjuvants
for the Delivery of Protein-Based Antigens. Submitted to Biomacromolecules
Recently accepted papers
Jones, KS (2008) Assays on the influence on biomaterials on allogeneic
rejection in tissue engineering. Tissue Engineering, Part B, Reviews
Dong, Y and Jones, KS (2008) Effect of alginate on innate immune activation
of macrophages. Journal of Biomedical Materials Research: Part A.
Jones, K.S. (2008) Biomaterials as Vaccine Adjuvants. Biotechnology Progress.
Mikhail, A.S. Jones, K.S., Sheardown, H.S. (2008) Dendrimer Grafted Cell
Adhesion Peptide Modified PDMS. Biotechnology Progress.
Jones, K.S. (2008) Effects of biomaterial-induced inflammation
on fibrosis and rejection. Seminars in Immunology. 20(2):130-6.
Jones, K.S., Gorczynski, R.M., Sefton, M.V. (2006) Suppressed splenocyte
proliferation following a xenogeneic skin graft due to implanted biomaterials.
Transplantation, 2006 Aug 15;82(3):415-21
Jones, K.S., Gorczynski, R.M., Sefton, M.V. (2004) In vivo recognition
by the host adaptive immune system of microencapsulated xenogeneic cells.
Transplantation. 2004 Nov 27;78(10):1454-62
Jones, K.S., McKersie, B.D., Paroschy, J. (2000) Prevention of ice propagation
by permeability barriers in bud axes of Vitis vinifera. Can. J. Bot. 78:
McKersie, B.D., Murnaghan, J., Jones, K.S., Bowley, S.R. (2000) Iron-superoxide
dismutase expression in transgenic alfalfa increases winter survival without
a detectable increase in photosynthetic oxidative stress tolerance. Plant
Physiol. 122: 1427-1437.
Jones, K.S., Paroschy, J., McKersie, B.D., Bowley, S.R. (1999) Carbohydrate
composition and freezing tolerance of canes and buds in Vitis vinifera.
J. Plant Phys. 155: 101-106.
McKersie, B.D., Bowley, S.R., Jones, K.S. (1999) Winter survival of transgenic
alfalfa overexpressing superoxide dismutase. Plant Physiol. 119: 839-847.
McKersie, B.D., Bowley, S.R., Jones, K.S., Gossen, B. (1999) Winter survival
of transgenic Medicago sativa over-expressing superoxide dismutase. In
M.F. Smallwood, Calvert, C.M. and Bowles (eds.) Plant Responses to Environmental
Stress, Bios Scientific Publishers.
McLean, D., Jones, K.S. and Hoare, T. (2008) Novel vaccine adjuvants:
Polymer microgels. Patent application submitted March 2008.
McKersie, B.D., Bowley, S.R. Jones, K.S., Samis, K. (2003) Enhanced Storage
Organ Production in Plants. U.S. Patent No. 6,518,486.